2010 Bio 317 Lecture 9

2010 Bio 317 - BIO 317 Lecture 9 Prof Arianna Maffei Office 548 Life Sciences Building Office Hours Tuesdays 11:30 AM 12:30 PM or by appointment

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Prof. Arianna Maffei Office: 548 Life Sciences Building Office Hours: Tuesdays, 11:30 AM - 12:30 PM or by appointment Recommended Reading: Handout#1 – Myastenia Gravis BIO 317: Lecture 9
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Summation of Synaptic Potentials
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Synaptic dynamics Short term Depression: Most of the Meaning is carried By the first few Presynaptic action potentials Short term facilitation: Most of the Meaning is carried By the last few Presynaptic action potentials Modified from Bierlein et al, 2003
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Synaptic Plasticity
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Possible Mechanisms
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Basic functional implication for synaptic plasticity Plasticity in Aplysia Bioscience Reports, Vol. 21, No. 5, October 2001 ( 2002) The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses Eric R. Kandel1
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The rodent hippocampus
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Long-term potentiation of Schaffer collateral-CA1 synapses
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LTP of Schaffer collateral-CA1 synapses
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LTP of Schaffer collateral-CA1 synapses
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LTP of Schaffer collateral-CA1 synapses
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LTP at a CA1 pyramidal neuron receiving inputs from two independent pathways
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Long-Term Potentiation (LTP)
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Pairing presynaptic and postsynaptic activity causes LTP
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LTP Requires Depolarization of Postsynaptic Neuron Synaptic strengthening occurs when neurotransmitter binds to depolarized post synaptic membrane.
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The NMDA receptor channel can open only during depolarization
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Signaling mechanisms underlying LTP
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LTP LTD Presynaptic neuron Presynaptic neuron LTP and LTD: An Embarrassment of Riches Robert C. Malenka1,* and Mark F. Bear2 Neuron, Vol. 44, 5–21, September 30, 2004
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This note was uploaded on 03/28/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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2010 Bio 317 - BIO 317 Lecture 9 Prof Arianna Maffei Office 548 Life Sciences Building Office Hours Tuesdays 11:30 AM 12:30 PM or by appointment

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