{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

2010 Bio 317 Lecture 9

2010 Bio 317 Lecture 9 - BIO 317 Lecture 9 Prof Arianna...

Info icon This preview shows pages 1–19. Sign up to view the full content.

View Full Document Right Arrow Icon
Prof. Arianna Maffei Office: 548 Life Sciences Building Office Hours: Tuesdays, 11:30 AM - 12:30 PM or by appointment Recommended Reading: Handout#1 – Myastenia Gravis BIO 317: Lecture 9
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Summation of Synaptic Potentials
Image of page 2
Synaptic dynamics Short term Depression: Most of the Meaning is carried By the first few Presynaptic action potentials Short term facilitation: Most of the Meaning is carried By the last few Presynaptic action potentials Modified from Bierlein et al, 2003
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Synaptic Plasticity
Image of page 4
Possible Mechanisms
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Basic functional implication for synaptic plasticity Plasticity in Aplysia Bioscience Reports, Vol. 21, No. 5, October 2001 ( ° 2002) The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses Eric R. Kandel1
Image of page 6
The rodent hippocampus
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Long-term potentiation of Schaffer collateral-CA1 synapses
Image of page 8
LTP of Schaffer collateral-CA1 synapses
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
LTP of Schaffer collateral-CA1 synapses
Image of page 10
LTP of Schaffer collateral-CA1 synapses
Image of page 11

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
LTP at a CA1 pyramidal neuron receiving inputs from two independent pathways
Image of page 12
Long-Term Potentiation (LTP)
Image of page 13

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Pairing presynaptic and postsynaptic activity causes LTP
Image of page 14
LTP Requires Depolarization of Postsynaptic Neuron Synaptic strengthening occurs when neurotransmitter binds to depolarized post synaptic membrane.
Image of page 15

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The NMDA receptor channel can open only during depolarization
Image of page 16
Signaling mechanisms underlying LTP
Image of page 17

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
LTP LTD Presynaptic neuron Presynaptic neuron LTP and LTD: An Embarrassment of Riches Robert C. Malenka1,* and Mark F. Bear2 Neuron, Vol. 44, 5–21, September 30, 2004
Image of page 18
Image of page 19
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern