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2010 Bio 317 Lecture 10

2010 Bio 317 Lecture 10 - BIO 317 Lecture 10 Prof Arianna...

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Prof. Arianna Maffei Office: 546 Life Sciences Building Office Hours: Tuesdays, 11:30 AM - 12:30 PM or by appointment Recommended Reading: handout BIO 317: Lecture 10
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Sensory Transduction Membrane sensors consisting of specialized ion channels translate sensory information into electrical signals sensory transduction channels generator potential How does the nervous system detect properties of the environment? Many sensory modalities: smell taste vision hearing touch pain temp. osmolarity C0 2 pH heat radiation electrical potentials
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Sensory Receptors General Properties There are five major types of sensory receptors – Chemoreceptors – Mechanoreceptors – Thermoreceptors – Photoreceptors – Electroreceptors Each receptor cell responds to a specific modality Exteroreceptors - monitor stimuli from outside the body Interoreceptors - monitor signals produced within the body
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Schematic of Sensory Transduction stimulus generator potential spike train or neurotransmitter release receptor molecule transduction channel receptor molecule responds to a specific stimulus receptor molecule may be the transduction channel or may communicate to transduction channel via second messenger generator potential is caused by opening (most common) or closing of cation channels: open depolarization close hyperpolarization generator potential controls rate of APs or rate of neurotransmitter released
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Light pressure activates a rapidly adapting touch- sensitive neuron Moderate pressure activates a slowly adapting pressure- sensitive neuron Strong pressure activates a slowly adapting nociceptor (pain) neuron
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Sensory Receptors Sensory receptors found in human skin Sensory receptors involved in proprioception
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Sensory Transduction Channels Transduction channels are hard to study Often located in fine nerve endings or small primary sensory cells Few specific toxins evolved for transduction channels Two techniques have been successful Patch clamp analysis of isolated primary sensory cells Identification and characterization of genes that affect sensory transduction
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Mechanisms of Response Three basic modes of response – A. receptor cell is a neuron with its cell body
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