2010 Bio 317 Lecture 17

2010 Bio 317 Lecture 17 - 11/1/10 Ca+/calmodulin-dependent...

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11/1/10 1 Ca ++ /calmodulin-dependent protein kinase Ac#va#on of CaM Kinase II or IP 3 domain
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11/1/10 2 Figure 15-44 Molecular Biology of the Cell (© Garland Science 2008)
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11/1/10 3 Figure 15-45 Molecular Biology of the Cell (© Garland Science 2008) Signaling and Growth Control
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11/1/10 4 Normal Fibroblasts Transformed Fibroblasts
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11/1/10 5 Varmus Bishop Retrovirus Ray Erikson c-src protein structure
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11/1/10 6 Bart Sefton Tony Hunter
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11/1/10 7 Src Ubiquitous but also two neuron-specific isoforms Fyn Ubiquitous, but also T cell-specific isoform (Fyn T) Yes Ubiquitous Lyn Brain, B-cells, myeloid cells; two alternatively spliced forms Hck Myeloid cells (two different translational starts) Fgr Myeloid cells, B-cells Blk B-cells Lck T-cells, NK cells, brain Frk Primarily epithelial cells Src Family Kinases Member Src kinases are multi-functional and exist in multiple sub-cellular locations Src kinases are involved in the control of many functions, including cell adhesion, growth, movement and di f erentiation, by phosphorylating a variety of substrates.
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This note was uploaded on 03/28/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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2010 Bio 317 Lecture 17 - 11/1/10 Ca+/calmodulin-dependent...

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