2010 Bio 317 Lecture 18

2010 Bio 317 - Enhanced by GTPase activating protein Signaling Pathways 6 Ras activation cycle 7 Ras activation cycle Ras activating mutation

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11/3/10 1 Carcinogen = Mutagen? Can human cancer be caused by mutation of a cellular gene that becomes dominant? Discovery and manipulation of v-src and c-src demonstrated that loss of growth control can be caused by a dominantly acting mutant of a cellular gene. control + mutagen Polycyclic Aromatic Hydrocarbons
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11/3/10 2 smokers non-smokers Bruce Ames rules!
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11/3/10 3 Carcinogen = Mutagen? Can human cancer be caused by mutation of a cellular gene that becomes dominant? Discovery and manipulation of v-src and c-src demonstrated that loss of growth control can be caused by a dominantly acting mutant of a cellular gene. Robert Weinberg
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11/3/10 4 cloning of the Frst human oncogene
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11/3/10 5 GDP Inactive GTP Active GTP GDP P i Intrinsic GTP hydrolysis Enhanced by exchange factors
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Unformatted text preview: Enhanced by GTPase activating protein Signaling Pathways 11/3/10 6 Ras activation cycle 11/3/10 7 Ras activation cycle Ras activating mutation inhibitory mutation X X Are src and ras connected in a common cell growth control pathway? Src* X anti-Ras Ras* anti-Src no block 11/3/10 8 Tyrosine kinase (src) ? Ras protein kinase protein kinase protein kinase Stanley Cohen EGF 11/3/10 9 GEF GEF /GEF 11/3/10 10 GEF EGF EGFR Note: Sos = GEF Erk = MAPK proto-oncoprotein pathway GEF 11/3/10 11 At the plasma membrane, Src can amplify and transduce signals from receptors to convey signals to the nucleus, cytoskeleton and other cellular components to control, for example, cell growth and proliferation (MAP kinase family)...
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This note was uploaded on 03/28/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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2010 Bio 317 - Enhanced by GTPase activating protein Signaling Pathways 6 Ras activation cycle 7 Ras activation cycle Ras activating mutation

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