2010 Bio 317 Lecture 21

2010 Bio 317 Lecture 21 - 11/17/10 PIP3 PDK1/2 targets PKB...

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11/17/10 1 PIP 3 PKB targets PDK1/2 NGF/TrkA
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11/17/10 2 ? targets PIP 3 PKB targets PDK1/2 Branched Signaling by Trk
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11/17/10 3 PKB Signaling Over Time and Space
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11/17/10 4 1. Why do NGF and EGF actions differ in neurons? 2. Why do the EGF receptor (proto-oncogene) and the EGFR oncogene have different effects in neurons? Signaling Over Time and Space
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11/17/10 5 Differential signaling over time by NGF and EGF +NGF +EGF PC12 cells Erk activation Erk Erk MEK MEK Sustained Erk kinase signaling
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11/17/10 6 Erk kinase
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11/17/10 7 Receptor-mediated endocytosis via clathrin Plasma Clathrin-coated Ruffle actin Early Endosome Macroendosome Rab5 Rab5 EEA1 Rabe Ank Multivesicular Bodies P R Ank Rab5 Rabe Rab5 Ank Rabe Rab5 Rab7 P P Pit Membrane Ank Rab5 Ank Rabe Rab5 P Late endosome/ Lysosome P-Erk P-Erk P-Erk X P-Erk P-Erk P-Erk P-Trk P-Trk P-Trk P-Trk P-EGFR P-EGFR EGFR X nucleus nucleus P-EGFR Endosomal Signaling
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11/17/10 8 Cell Surface Endosome Rap B-Raf Erk locale KSR MP1
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11/17/10 9 Peripheral Nervous System Central Nervous System NGF responsive neuron NGF responsive neuron
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This note was uploaded on 03/28/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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2010 Bio 317 Lecture 21 - 11/17/10 PIP3 PDK1/2 targets PKB...

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