2010 Bio 317 Lecture 22

2010 Bio 317 Lecture 22 - Subcellular Compartmentation of...

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1 Subcellular Compartmentation of Signaling: Anchoring and Scaffolding
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2 Cell Surface Endosome Rap B-Raf p14 A-kinase Anchoring Protein (AKAP)
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3 AKAPs localize kinases with specifc substrates
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4 Interactions Between Signaling Pathways - Crosstalk GiGTP Signaling Crosstalk +/- NT or NT or
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5 1. G-proteins have common effector, e.g. AC--> cAMP 2. 2nd messenger interaction, e.g. Ca --> AC --> cAMP Among G-protein linked pathways Between pathways 1. Common effector pathway, e.g. PLC --> PIP 2 breakdown 2. Cross regulation of pathways, e.g. Ca --> Ras; PKC --> Raf Convergence at endpoint e.g. Tyrosine hydroxylase phosphorylation Modes of Crosstalk
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6 Ca 2+ T r k NGF Ras Raf MEK Glycogen Breakdown in Muscle
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7 Higher-order View of Signaling: Networks Signaling networks are analyzed from various viewpoints. 1. View from a particular input and analyzing the entire network as a stand alone system.
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Signaling networks are analyzed from various viewpoints. 1. View from a particular input and analyzing the entire network
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This note was uploaded on 03/28/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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2010 Bio 317 Lecture 22 - Subcellular Compartmentation of...

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