2010 Bio 317 Lecture 24

2010 Bio 317 Lecture 24 - 12/1/10 CREB on CRE Alphahelix...

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12/1/10 1 CREB on CRE MG 2+ Leucine Zipper Alpha‐helix Attenuation Due to S/T Phosphatase PP-1 Passive Difusion
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12/1/10 2 CBP - Increase of Gene Expression 1.Histone acetyltransferase – Acetylates lysine residues 2. Bind factors involved in cell growth and diFerenbabon 3. Recruitment of ±asal transcripbon machinery (RNA Pol‐II)
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12/1/10 3 Figure 15-60 Molecular Biology of the Cell (© Garland Science 2008) MAPK rsk
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12/1/10 4
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12/1/10 5 Nuclear Hormone Receptors Pathologies e.g. Diabetes, Cancer, Osteoporosis Ligand-Inducible Transcription Factors Involved in Growth, Differentiation & Homeostasis
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12/1/10 6 Nuclear Hormone Receptors • 48 (humans so far) • Activated by ligands Readily diffuse • Bind intracellular receptor ( Nucleus) Gene regulatory – Steroid hormones (Cortisol, Testosterone, Ecdysone…) – Thyroid hormones (Thyroxine T4, Triiodothyronine T3) – Retinoids – Vitamin D • Receptor activation TRANSCRIPTIONAL ACTIVATION Nuclear Signaling Molecules “Stress Hormone” “Anabolic Steroid” “Pregnancy Hormone” “Regulator of Metabolism” Ca 2+ & P Homeostasis “Growth, development, differentiation”
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12/1/10 7 Estrogens
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2010 Bio 317 Lecture 24 - 12/1/10 CREB on CRE Alphahelix...

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