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2010 Bio 317 Lecture 25

2010 Bio 317 Lecture 25 - Nuclear Receptors 2 1 THE DNA...

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12/6/10 1 Nuclear Receptors 2
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12/6/10 2 C N C THE DNA BINDING DOMAIN AGGTCA (Non steroid receptors and ER) AGAACA (Steroid receptors) cGSc k V cEGc P Box GR ER D Box Dimerization CTE C C C C Zn C C C C Zn C P Box C N D Box P D Zinc finger
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12/6/10 3 Target Gene Specificity - Hormone Response Elements HRE’s- 12-17 nucleotides Hexad Variability Rules: The 1-2-3-4-5 Rule Non-steroidal nuclear receptors that function as heterodimers with the retinoid X receptor (RXR) recognize the direct repeat of the hexad AGGTCA, which is separated by one to five nucleotides (n). RXR can form homodimers. NGF-1B, nuclear-growth-factor-inducible receptor; PPAR, peroxisome proliferator-activated receptor; RAR, retinoic acid receptor; TR, thyroid-hormone receptor; VDR, vitamin D receptor.
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12/6/10 4 How Do Nuclear Receptors Activate Transcription? Chromatin Structure
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12/6/10 5 Nucleosome Assembly Defining the Nucleosome
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12/6/10 6 Transcription Activation Complex P300 & CBP - Increase of Gene Expression 1. Histone acetyltransferase – Acetylates
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