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Unformatted text preview: about how signaling pathways that regulate gene expression are integrated and/or modulated. a) CBP/p300 can act as a central integrator of multiple signaling pathways that use it as a co-activator, such as those involving nuclear receptors, CREB and Sap1. b) Gene expression modules may contain transcription factors directly responsive to signaling pathways or transcription factor products of primary response genes. c) The actions of nuclear hormone receptors can be modulated by phosphorylation by protein kinases activated by signaling pathways and/or the cell cycle. d) CREB can be phosphorylated by A-kinase or CaM kinase to activate transcription. e) All of the above. 25) The following is NOT true about how changes in gene expression are related to maternal licking/grooming (LG) behavior. a) High maternal LG behavior results in female offspring with low maternal LG behavior, due to upregulation of hippocampal GR receptor levels and a resulting low tolerance to stress. b) Serotonin, released in offspring in response to maternal LG behavior, results in increased expression of NGF1-A, a cAMP-responsive primary response gene. c) NGFI-A binds to a regulatory sequence in the promoter of the GR gene, resulting in increased GR gene expression. d) TSA is a Histone Deacetylase (HDAC) inhibitor, which can partially reverse the effects of low maternal LG on the behavior of offspring. e) None of the above....
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This note was uploaded on 03/28/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.
- Fall '08