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2010 Fall Bio 317 Exam 3

D mp1 provides a scaffold for mek and erk on

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Unformatted text preview: alysis of the effector interactions among different receptor tyrosine kinases. c) Modeling and combining mini-networks of the inputs and outputs of Ras family members. d) Modeling a complete signaling network encompassing all signaling pathways operating in a particular cell type. e) All of the above. 14) The following is true of kinase-type receptor signaling pathways. a) Receptor tyrosine kinases bind their ligands, which cause activation of the kinases contained within the extracellular ligand-binding domain. b) A class of cytokine receptor utilizes a non-enzymatic, ligand-bound receptor, which binds to and thus conformationally activates a transcription factor. c) The Smad transcription factors are phosphorylated by receptor tyrosine kinases such as EGFR, resulting in their activation. d) The STATs are a class of transcription factor that is phosphorylated on tyrosine by JAK kinase and forms a dimer through its own SH2-phosphotyrosine interactions. e) None of the above. 15) The following is true of how signaling pathways regulate gene expression. a) The transport and localization of mRNA in the nucleus can be altered. b) The rate of DNA replication is changed. c) The rate of protein synthesis can be stimulated by the action of Erk on MNK1 to enhance the formation and function of translation initiation complexes on mRNA. d) The rate at which RNA is capped after transcription is regulated. e) The speed with which RNA chains are elongated during transcription is regulated. 16) The following is NOT true of the CRE (cAMP Response Element). a) It works best when within 100 bp from the TATA box. b) It was discovered using deletion analysis of the somatostatin gene promoter linked to DNA encoding a luciferase reporter, as a DNA element responsible for transcriptional activation upon cAMP elevation. c) It is an 8-base pair palindrome of TGACGTCA located within a cAMP-regulated, TATA box-containing gene promoter. d) It can act on any reporter gene linked to any TATA box-containing promoter. e) None of the above. 17) The following is NOT true of the CREB transcription f...
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