2010 Bio 320 Lecture Guide 21 + 22

2010 Bio 320 Lecture Guide 21 + 22 - Study Guide Eukaryotic...

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Study Guide – Eukaryotic chromosomes, chromatin and gene regulation. Overview This sequence of lectures takes up the regulation of gene expression again. The same basic mechanisms outlined in the bacterial operon are now applied to gene regulation in eukaryotes. A new ingredient is the packaging of DNA into chromatin: modifications of the chomatin proteins and of the DNA itself help to maintain stable expression patterns. Semi-stable changes that can persist thorough cell division, but do not change the underlying base sequence are called epigenetic . Genomic imprinting is a special case in which epigenetic changes in the parental germline regulate gene expression in their offspring. Other new features of eukaryotic gene regulation the regulation of stepps after transcription. RNA interference is a recently discovered mechanism by which short dsRNA molecules can trigger either the destruction of transcripts with which they share a sequence, or suppress their translation. In general, you should know the meaning of the terms below, be able to distinguish
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2010 Bio 320 Lecture Guide 21 + 22 - Study Guide Eukaryotic...

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