2010 Bio 320 Lecture Guide 23 + 24

2010 Bio 320 Lecture Guide 23 + 24 - Study Guide - lectures...

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Study Guide - lectures 23-24 (listed in the syllabus as topics 22-23). Overview & goals These lectures show how gene regulation controls the development of multicellular organisms, and how genetics is used as a tool to understand complex developmental pathways. First, we deal with the control of cell proliferation: how a dedicated cellular “clockwork” ensures the orderly progress of the cell division cycle, and how conditional mutants were used to identify the proteins in this mechanism., Failure to regulate cell division is the basis of cancer in multicellular animals: cancer- causing oncogenes promote tumor formation, especially if tumor suppressor genes that normally keep cell division in check are mutated. In the second lecture, we show how the complex sequence of events that changes a single fertilized zygote into a multilayered, differentiated embryo depends on changes in gene expression at the cellular level. Finally, we take one example of developmental patterning - segmentation of the Drosophila embryo – and show how it is controlled by the expression and action of transcriptional activators and repressors, themselves discovered in genetic screens. At the end of this sequence, you should…
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This note was uploaded on 03/28/2011 for the course BIO 320 taught by Professor N/a during the Spring '08 term at SUNY Stony Brook.

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2010 Bio 320 Lecture Guide 23 + 24 - Study Guide - lectures...

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