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2010 Bio 320 Lecture Guide 25 + 26

2010 Bio 320 Lecture Guide 25 + 26 - Study Guide lectures...

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Study Guide - lectures 25-26: Population and quantitative genetics. Overview & goals These lectures deal with genetic diversity in populations – especially human populations. We begin by outlining some basic principles of population genetics , establishing that (with some assumptions) allele frequencies don’t change - then look at they ways in which they do. After this section, you should: - Understand what is meant by the “gene pool” model and Hardy-Weinberg-Castle (HWC) equilibrium. - be able to calculate allele frequencies from genotype frequencies, and vice versa, in HWC conditions; - be able to predict the effects of mutation, selection, genetic drift and non-random mating on allele frequencies and polymorphism levels in a population. We then look at what is currently known about actual human genetic diversity, from genotyping and sequencing data. You will recall (lectures 19-20) what a haplotype is. Now we show how distinct haplotypes arise by accumulating neutral mutations, how they are reshuffled by recombination, and how present-day haplotypes can be used to trace patterns of human ancestry and migration. We will also look at some evidence for very recent selection and ongoing human evolution. Some of this recent research is
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