2010 Bio 320 Midterm 2 Answers

2010 Bio 320 Midterm 2 Answers - Explanations of some...

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Explanations of some midterm questions that were answered correctly by fewer than half of the students. These are from the BLUE version of the exam. Numbers in brackets show the number of people giving each answer. 2 . Which of the following cannot be used as a marker in constructing a linkage map? A. A restriction fragment length polymorphism (RFLP) site. (3) B. A dominant mutation with a visible phenotype, in an unidentified gene. (49!) C. A microsatellite or short tandem repeat locus with polymorphic repeat numbers. (6) D. A long, conserved open reading frame. (26) E. A single nucleotide polymorphism (SNP). (10) Correct answer: D. Linkage maps order loci according to the observed frequencies of recombination between them. The essential property of a marker used to construct a linkage map is that it exists in alternate versions (i.e., alleles, or polymorphisms), so that recombinant haplotypes can be distinguished. A visible mutation (B) can serve as a marker even if the gene is unidentified – remember that linkage maps were made well before DNA was known to be the genetic material, let alone sequenced. Or a marker can be any type of
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This note was uploaded on 03/28/2011 for the course BIO 320 taught by Professor N/a during the Spring '08 term at SUNY Stony Brook.

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2010 Bio 320 Midterm 2 Answers - Explanations of some...

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