Lecture 5 Synaptic Transmission 1

Lecture 5 Synaptic Transmission 1 - Synaptic Transmission 1...

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Synaptic Transmission 1 Structure and Function of Neurotransmitter Receptors
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- integral ion channel, gated by ligand binding - multiple subunits - fast synaptic transmission Acetylcholine - nicotinic GABA - GABA A Glycine Glutamate - AMPA - Kainate - NMDA ≈100 genes - ligand binding activates G-protein - single polypeptide - 7 membrane spanning regions - slow synaptic transmission Acetylcholine - muscarinic GABA - GABA B Glutamate - metabotropic Noradrenaline Serotonin - 5Ht1 ATP - P 2Y , P 2U Neuropeptides - substance P Dopamine ≈ 500 genes G-Protein Linked Receptors Ligand-Gated Ion Channels
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Excitatory - cation selective Na + , K + acetylcholine, glutamate Inhibitory - anion selective Cl - GABA, glycine
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Hydropathy Plot amphipathic leader sequence Structure of the Nicotinic Acetylcholine Receptor
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pentamer α 2 βγ δ
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cation channel Ion Permeation through the Acetylcholine Receptor
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electrostatic
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external intermediate internal M2 single channel conductance
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Gating of the Acetylcholine Receptor
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ACh binding energy induces a conformational change
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- integral ion channel, gated by ligand binding - multiple subunits - fast synaptic transmission Acetylcholine - nicotinic
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This note was uploaded on 03/28/2011 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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Lecture 5 Synaptic Transmission 1 - Synaptic Transmission 1...

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