Lecture 10 Cardiac Action Potentials

Lecture 10 Cardiac Action Potentials - Cardiac Action...

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Unformatted text preview: Cardiac Action Potential and G-Protein-Linked Receptors William Harvey (1628) Cardiovascular System Pump- heart Tubing- blood vessels (vascular system) Control system - autonomic nervous system myocardium myocyte striated muscle myocyte 6 connexins = 1 connexon (hemichannel) electrical syncytium Multiple Cell Types in Heart Pacemaker cells- primarily in sinoatrial (SA) node Conducting cells- atrioventricular (AV) node- bundle of His- Purkinje fibers Working Myocardium- bulk of atrial myocytes- bulk of ventricular myocytes Sequence of Electrical Excitation 1. SA node 2. bulk of atrial muscle 3. AV node- slow conduction allows atrial contraction to complete 1. bundle of His- passes through a non-conducting layer of connective tissue separating atria and ventricle 1. bundle branches 2. Purkinje fibers 3. bulk of ventricle muscle HCN4 inward rectifier I A like I M Na/Ca exchanger Electrocardiogram ECG Q-T interval...
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This note was uploaded on 03/28/2011 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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Lecture 10 Cardiac Action Potentials - Cardiac Action...

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