Lecture 13 Regulation of Electrophysiological

Lecture 13 Regulation of Electrophysiological - Regulation...

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Unformatted text preview: Regulation of Electrophysiological Phenotypes Nervous system has to do two somewhat contradictory things. Stability Personality, perceptions and memories remain relatively stable throughout adult life even though the underlying physical substrate will have changed: proteins will have turned over many thousands of times, there will have been rearrangement of synaptic connections and some local circuitry, and at least some neurons will have died and others born. Plasticity You can learn new skills and form new memories throughout life suggesting that the nervous system retains the ability able to reorganize certain aspects of its function. Sources of Stability 1. Selection for robust networks- purifying selection acting on protein sequence/function- purifying selection acting on gene expression 2. Homeostatic feedback loops- during development- in the adult Role of Electrical Activity in Regulating the Electrophysiological Phenotype Effects of Denervation on Skeletal Muscle 1. Atrophy 2. Denervation supersensitivity 3. Changes in Na + channel isoform expression- change in TTX sensitivity 1. Changes in contractile protein expression- myosin isoform expression Atrophy following Partial Denervation Effect of Innervation on AChR Expression Denervation Supersensitivity Normal Denervated Changes in Na + Channel Isoform Expression Na v 1.5 Na v 1.4 Effects of Denervation on Skeletal Muscle 1. Atrophy 2. Denervation supersensitivity 2....
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This note was uploaded on 03/28/2011 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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Lecture 13 Regulation of Electrophysiological - Regulation...

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