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Lecture 20 Kidney I

Lecture 20 Kidney I - Renal Physiology Lecture 1 Anatomy of...

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Renal Physiology Barbara Rosati Dept. Physiology and Biophysics, BST 6-122 Phone: (631) 444-7350; E-mail: [email protected] Mincturition Lecture 1. Anatomy of the Urinary System Functions of the Nephron 1. Filtration 2. Reabsorption 3. Secretion 4. Excretion
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Renal Physiology Barbara Rosati Dept. Physiology and Biophysics, BST 6-122 Phone: (631) 444-7350; E-mail: [email protected] Lecture 2. Integrated Kidney Function 1. Water balance 2. Sodium and ECF balance 3. Potassium balance 4. Calcium balance 5. Acid-Base balance Suggested reading: “Vander’s Human Physiology, 12ed., Chapt.14.
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Anatomy of the Urinary System- I Aorta Superior Vena Cava Renal Artery Renal Vein
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Functions of the Kidneys 1. Regulation of ECF volume and blood pressure 1. Regulation of osmolarity 1. Maintenance of ionic balance 1. Homeostatic control of pH 1. Elimination of catabolites and waste 1. Production of hormones
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Anatomy of the Urinary System- II
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Anatomy of the Urinary System- III Cortical nephron nephron
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Anatomy of the Urinary System- IV From Renal artery To Renal vein Cortical nephron Juxtamedullary nephron
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1. Filtration 2. Reabsorption 3. Secretion 4. Excretion Functions of the Nephron
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Relationship between nephron functions
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1. Filtration 2. Reabsorption 3. Secretion 4. Excretion Functions of the Nephron
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Filtration: The Renal Corpuscle
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Filtration: The Renal Corpuscle
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Filtration Pressure P H = Hydrostatic (blood) pressure π = Colloid osmotic pressure P fluid = Hydrostatic (Bowman’s fluid) pressure
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Filtration Fraction An average of 180 L/day are filtered by the kidneys = = Glomerular Filtration Rate (GFR)
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Autoregulation of GFR
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Mechanisms of GFR Autoregulation (Intrinsic Regulation) 1. Myogenic Response
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Lecture 20 Kidney I - Renal Physiology Lecture 1 Anatomy of...

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