2006 Fall Bio 328 Exam 2

2006 Fall Bio 328 Exam 2 - BIO 328 Examination 2 6 November...

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BIO 328 Examination 2 6 November 2006 Page 1 FOR EACH QUESTION, SELECT THE MOST INCORRECT ANSWER Mark your answers on the op-scan sheet with a No.2 pencil. If you change your answer, be sure to erase thoroughly. There are 25 Questions on this examination so be sure to answer all of them. Fill in your name and SBU ID number (NOT YOUR SS#) on the answer sheet. 1) Cellular constituents of the central nervous system: a) Differing neuronal dendritic morphologies of CNS interneurons are widespread and often presage differences in location and/or function. b) Astrocytes, while not directly involved in synaptic communication between neurons, often perform the important function of inactivating neurotransmitters/neuromodulators released by presynaptic nerve terminals. c) The choroid plexus, composed of specialized neuroglial cells, is located in the lateral, 3 rd , and 4 th ventricles, and manufactures and secretes cerebrospinal fluid (CSF) at a rate of 500 ml/day. d) Microglia are glia that act similarly to macrophages. e) Oligodendrocytes are CNS glial cells that serve a similar function as Schwann cells in the peripheral nervous system. 2) Blood brain barrier: a) Requires normal functioning astrocytes. b) Passage of large molecules into brain ECF is limited, in part, because adjacent endothelial cells in brain capillaries form tight end-to-end appositions. The formation of tight junctions significantly differentiates brain capillaries from typical capillaries in skeletal muscle. c) Glucose, because it is lipophobic, cannot enter the brain ECF in sufficient concentrations to meet the brain’s metabolic needs by simple diffusion. d) The smaller and more lipophilic a molecule, the greater the likelihood the molecule will penetrate the blood brain barrier. Typically, addictive molecules like nicotine and ethanol exhibit high lipid solubility. e) A reason morphine remains in brain longer than heroin, is that greater concentrations of morphine cross the blood brain barrier since morphine is more lipid soluble than heroin. 3) Spinal cord: a) Dorsal roots contain sensory axons whose terminal endings synapse in the CNS, while ventral roots contain motor axons whose terminal endings form one portion of the neuromuscular junction. b) The ventral horn changes shape as one goes in a rostral-caudal direction. The ventral horn in lumbar spinal cord is larger than ventral horn in thoracic spinal cord. c) Ventral horn contains motor neuron cell bodies that innervate striated and smooth muscle below the head and neck. d) White matter contains large numbers of unmyelinated axons. e) The dorsal horn and ventral horn are gray matter in spinal cord. 4) Brain stem and cerebellum: a) If you shine a pen light into a comatose individual’s right eye, and the pupil does not constrict, a restricted area of the brainstem below the level of the pons is likely to be damaged.
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This note was uploaded on 03/28/2011 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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2006 Fall Bio 328 Exam 2 - BIO 328 Examination 2 6 November...

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