lecture 4 2011

lecture 4 2011 - Lecture 4 Ghrelin • Discovered in 1999...

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Unformatted text preview: Lecture 4 Ghrelin • Discovered in 1999 • 28 aa protein – Posttranslational modification: acylated with an 8 carbon fatty acid (octanoate) by ghrelin O-acyltransferase (GOAT or MBOAT4) Ghrelin • Stomach lining produces 65-80% of circulating ghrelin – Empty stomach = high ghrelin – Filling stomach with water/air balloon does not depress ghrelin levels because not calories. Actions of Ghrelin • Hunger • Feeding • Body weight • Fat mass • Growth hormone Actions of Ghrelin • During extended fasts – decreased energy expenditures – Decreased insulin – Decreased fat oxidation – Decreased core body temperature Ghrelin plasma levels • Decreased in obese individuals (diet induced) • Elevated in anorexia nervosa • Lower in humans with polycystic ovaries (even lower than in obese controls) Ghrelin receptor • Two forms – GHSR-1a – GHSR-1b Ghrelin and reproduction • Central/brain Ghrelin and reproduction • Gonad Ghrelin and reproduction • Embryo/implantation...
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This note was uploaded on 03/28/2011 for the course POUL 4060 taught by Professor Davis during the Spring '11 term at UGA.

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lecture 4 2011 - Lecture 4 Ghrelin • Discovered in 1999...

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