lecture 5 2011 - CNS/hypothalamus, testes, ovary, pancreas...

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Lecture 5
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Receptor GPR54 Discovered in 2003-2004 Loss of function point mutation in humans results in hypogonadotrophic hypogonadism A condition characterized by the absence of spontaneous pubertal development, low sex steroids and low gonadotrophins sterile unless give hormone treatment
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Receptor GPR54 Considered one of the biggest discoveries in human reproduction biology in 30 years since the discovery of GnRH in the 1970’s What binds to this receptor? Kisspeptin = metastin (original name) Discovered in the 1990’s as an antimetastasis factor in human breast carcinomas Used as a marker for metastatic from nonmetastatic cancers
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Kisspeptin Kiss-1 gene codes for 145 aa protein that is processed into a 54, 14, 13 and 10 amino acid forms that can all bind to GPR54 54 aa form kisspeptin Expression of kisspeptin and GPR 54
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Unformatted text preview: CNS/hypothalamus, testes, ovary, pancreas and placenta 7-9,000 fold increase plasma levels during pregnancy Kisspeptin Functions at the hypothalamus and pituitary Increase GnRH and thus LH and FSH (less potent) SCN = Part of the hypothalamus which receives information about light from retina and stimulates melatonin synthesis at night. Thus day length encoded by duration of melatonin secretion ovary Normal Ovulation In female rodents 2 major populations of neurons are sensitive to kisspeptin in hypothalamus: 1. ARC arculate nucleus 2. AVPV- antoventral periventricular nucleus Neurokinin B (TAC 3 or NKB) Protein hormone that is a member of the tachykinin protein family of excitatory neurotransmitters Receptor (TACR3 or NK3R) In 2009, Congenital hypogonadotrophic hypogonadism...
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This note was uploaded on 03/28/2011 for the course POUL 4060 taught by Professor Davis during the Spring '11 term at University of Georgia Athens.

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lecture 5 2011 - CNS/hypothalamus, testes, ovary, pancreas...

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