lecture 7 2011

lecture 7 2011 - • Food intake • Role in gonads beta LH...

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Lecture 7 Hypothalamus and pituitary
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GnRH Gonadotropin (gonadatrophin) releasing hormone Decapeptide produced by the hypothalamus Most vertebrates have 2 or 3 forms In mammals stimulates the production and release of both LH and FSH based pulsatile pattern of GnRH release Fast LH Slow FSH
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Birds 3 Forms of GnRH LHRH vs GnRH
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GnRH I vs GnRH II Physiologic control of LH production and release by GnRH I Present in high concentrations in hypothalamus Levels change with reproductive state (gonadal feedback Active immunization of laying hens against GnRH I but not GnRH II results in decreased LH and complete regression GnRH II function
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GnIH Gonadotropin inhibitory hormone (RFRP- 3) Discovered in quail in 2000, subsequently several mammalian species Receptor (GPR 147) in 2005 Produced by hypothalamus Inhibits gonadotropin synthesis and release Melatonin link
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GnIH New research focus points Inhibition of reproductive behavior Inhibition of GnRH production
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Unformatted text preview: • Food intake • Role in gonads beta LH subunit alpha subunit beta FSH subunit FSH LH Anterior Pituitary • LH (luteinizing hormone) • FSH (follicle stimulating hormone) – Glycoproteins with a common alpha subunit and distinct beta subunit • In mammals beta subunit rate limiting , alpha in excess • In birds, alpha not in excess both can be rate limiting LH • Misnamed • Associated with more developed follicles • Induces ovulation • Stimulates steroidogenesis • Stimulates follicular growth • Maintains hierarchy FSH • Associated with small follicles • Granulosa cell maturation • Increases estradiol production • Stimulates follicular growth • Maintains hierarchy Posterior Pituitary • Storage for – Vasotocin (vasopression) • Osmotic pressure • Smooth muscle contraction for egg laying • Male sexual behavior – Mesotocin (oxytocin) • Function unclear...
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