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Lecture 10-12 - Lectures 10-11 Click to edit Master...

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Click to edit Master subtitle style 3/29/11 Lectures 10-11
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3/29/11 Inhibin and Activin Inhibin Inhibits FSH secretion and release by inhibiting activin stimulation Activin Stimulates FSH secretion Follistatin Binding protein that binds activin and with less affinity inhibin. Binding prevents most activin functions
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3/29/11 Inhibin and Activin Glycoprotein hormones produced by many tissues but primary source in the gonads Genes and proteins isolated in late 1980’s Dimeric structure built from shared common subunits.
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3/29/11
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3/29/11 Inhibin α-subunit Tumor suppressor α-subunit gene knocked out in mice results in tumor formation in the ovaries and testes Free α-subunit in blood
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3/29/11 Ovarian Cancer 5th leading cause of death from all cancers in women Incidence is about 1 in 57 women Tumors normally not discovered to stage III or IV so 5 year survival rate only 5-40% 85-90% of cases arise from surface epithelium cells of the ovary, 5-7% from the stroma cells and 5-7% from
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