lecture 13 2011 - Prostaglandins 2nd messengers to some...

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Prostaglandins 2 nd messengers to some degree F 1 Stimulus for increase production is unknown Ovulation Plasminogen activator Smooth muscle Not required
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A 2
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Prostaglandins… Pain Fever Inflammation Reproduction Are responsible for mucus production and reduction of acid synthesis in the GI tract Increase blood flow to kidneys
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Phospholipids of Note Prostacyclins Inhibit blood platelet aggregation Thromboxane Promotes blood clotting Leukotrienes Form leukocytes and stimulate vascular contraction and permeability induces local inflamation Example: Asthma
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Cox 1 Cox 2 Phospholipase A 2 Steroidal anti-inflammatory drugs (cortisone) Asprin, Ibuprofen indomethacin Zyflo Singulair
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Human Adrenal Gland Medulla Catecholamines: Epinephrine and Norepinephrine Flight or fight response
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Adrenal Cortex 3 layers: Zona reticularis Androgens Zona fasciculata Glucocorticoids (cortisol and corticosterone) Zona glomerulosa Mineralocorticoids (aldosterone)
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Chromaffin cells are medulla cells
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Adrenal Steroids Aldosterone Induces reabsorption of Na by kidney, water follows
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This note was uploaded on 03/28/2011 for the course POUL 4060 taught by Professor Davis during the Spring '11 term at University of Georgia Athens.

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lecture 13 2011 - Prostaglandins 2nd messengers to some...

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