lecture 23 2011 - SH BG Ar omat ase is pr esent in fat...

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SHBG Aromatase is present in fat cells Bound vs unbound (free) steroid hormones Sex Hormone Binding Globulin Produced in liver Same amino acid sequence as ABP Binds testosterone, estradiol High insulin levels decrease expression
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As BMI increases Plasma/serum inhibin B, SHBG and total testosterone decrease while estradiol increases Free testosterone
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Probability of pregnancy increases when sperm count 40 million/ml or greater in humans
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Data from 101 sperm count studies conducted from 1934-1996
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Sperm Counts Always a big debate on whether sperm counts decreasing Confounding Factors Abstinence Uniform procedure Season How quickly sample is processed Smoking Collection Methods Geographical location
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Sperm Counts (cont.) Statistical Methods Poor Data (voluntary)
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6% of Danish children born through assisted reproduction, 30% of Danish men have semen quality in subfertile range Possible reasons for decrease
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lecture 23 2011 - SH BG Ar omat ase is pr esent in fat...

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