{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

lecture 24-26 2011

lecture 24-26 2011 - E st r ogen Recept or s(ER Tr adit...

Info iconThis preview shows pages 1–20. Sign up to view the full content.

View Full Document Right Arrow Icon
Estrogen Receptors (ER) Traditional Two Forms ER α and ER β Homology DNA binding domain 95% Homology ligand binding domain 60% Independent tissue regulation and distribution Binding affinity ER’s function as dimers ER α ER α , ER β ER β and ER α ER β Nuclear transcription
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Estrogen Receptors New Discoveries Plasma membrane Activate 2 nd messengers, kinase and phosphotase activation, calcium influx, etc Tethered nuclear ER Nonclassical steroid binding proteins SHBG receptor
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Dietary Estrogens Lignans, isoflavones, flavones and cuomestran Sheep over 60 years ago in Australia Rams became feminized and unable to breed, females unable to support pregnancy Cause – feeding on clover pasture, clover contains the isoflavones genistein and diadzien Genistein about 4-6 times less potent than estradiol with membrane receptors and 100-1000 times lower affinity for ER α
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 8
Soy, tofu, legumes have genistein Soy also used as flour or meal, also used often in processed foods Soy based infant formula Reduce Sertoli cell and germ cell numbers by increasing apoptosis in rats Reduce steroid synthesis Induce/accelerate human sperm cell capacitation and acrosome membrane breakdown
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 10
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 12
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 16
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 18
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 20
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}