Lecture 24-26 2011 - Estrogen Receptors(ER Traditional • Two Forms ER α and ER β – Homology DNA binding domain 95 – Homology ligand binding

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Unformatted text preview: Estrogen Receptors (ER) Traditional • Two Forms ER α and ER β – Homology DNA binding domain 95% – Homology ligand binding domain 60% • I ndependent tissue regulation and distribution • Binding affinity • ER’s function as dimers ER α ER α , ER β ER β and ER α ER β • Nuclear transcription Estrogen Receptors New Discoveries • Plasma membrane – Activate 2 nd messengers, kinase and phosphotase activation, calcium influx, etc – Tethered nuclear ER – Nonclassical steroid binding proteins • SHBG receptor Dietary Estrogens • Lignans, isoflavones, flavones and cuomestran • Sheep over 60 years ago in Australia – Rams became feminized and unable to breed, females unable to support pregnancy – Cause – feeding on clover pasture, clover contains the isoflavones genistein and diadzien – Genistein about 4-6 times less potent than estradiol with membrane receptors and 100-1000 times lower affinity for ER α • Soy, tofu, legumes have genistein • Soy also used as flour or meal, also used often in processed foods • Soy based infant formula • Reduce Sertoli cell and germ cell numbers by increasing apoptosis in rats • Reduce steroid synthesis • I nduce/accelerate human sperm cell capacitation and acrosome membrane breakdown Endocrine Disrupting...
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This note was uploaded on 03/28/2011 for the course POUL 4060 taught by Professor Davis during the Spring '11 term at University of Georgia Athens.

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Lecture 24-26 2011 - Estrogen Receptors(ER Traditional • Two Forms ER α and ER β – Homology DNA binding domain 95 – Homology ligand binding

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