Lecture_2_-_Jan_19

Lecture_2_-_Jan_19 - ATP is located in the middle of the...

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ATP is located in the middle of the thermodynamic hierarchy of phosphoryl-transfer agents
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High-energy compounds above ATP have additional de-stablilizing influences
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There are additional competing resonances in phosphoguanidines that contribute to the “high-energy” nature
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ATP serves as an energy conduit between high and low energy phosphate donors. Kinases couple the phosphoryl-transfer reactions ATP is highly utilized and must be continually regenerated
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Consumption of ATP 1. early stages of nutrient breakdown Exergonic hydrolysis of ATP to ADP is enzymatically coupled to an endergonic phosphorylation to form a “low-energy” phosphate compound
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Consumption of ATP 2. Interconversion of nucleoside triphosphates : ATP is the substrate for the biosynthesis or NTPs and dNTPs ATP + NDP ADP + NTP 3. Physiological processes : The hydrolysis of ATP energizes physiological processes, such as protein folding, muscle contraction, ion transport against a gradient.
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Consumption of ATP 4. Phosphoanhydride cleavage in highly endergonic reactions : ATP hydrolysis to AMP and PPi results in the hydroysis of 2 high-energy bonds
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a person need? ATP is not kept in “reserve” – it is continually being hydrolyzed and replenished. Adults need about 2800 kcal/day, or 11,700 kJ of energy. Assuming we lose about half to heat, we use about 5860 kJ/day. In vivo, 1 mole of ATP is about 50 kJ, so we use 117 moles of ATP/day. The MW of ATP is about 550 g/mol, so we use about
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Lecture_2_-_Jan_19 - ATP is located in the middle of the...

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