Lecture_3_-_Jan_21

Lecture_3_-_Jan_21 - Stage I (rxns 1-5): preparatory stage...

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G values in Table 17.1 Stage I (rxns 1-5): preparatory stage utilizes 2 ATPs Stage II (rxns 6-10): Convert 2x G3P compounds to pyruvate and yield 2 ATPs (4 ATPs generated)
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Step 2: Phosphoglucose isomerase Converts G6P to fructose-6- Phosphate (F6P) via isomerization of an aldose to a ketose.
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Phosphoglucose isomerase is stereospecific In base-catalyzed reaction, get both mannose-6-P and fructose-6-P
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Step 3: Phophofructokinase: Second ATP Utilization Phosphorylation of F6P to yield fructose-1,6-bis phosphate
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Step 4: Aldolase Cleavage of FBP To form 2 trioses: GAP and DHAP
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The structure of FBP is required for an aldol cleavage resulting in two C3 carbons C2 and C4 2-C3 molecules
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Step 5: Triose phosphate isomerase 1. Only GAP continues in glycolysis 2. GAP and DHAP are ketose-aldose isomers 3. Triose phosphate isomerase catalyzes the interconversion of DHAP to GAP 4. From this point forward, there are 2 GAP molecules for every glucose molecule Products from step 4 are GAP and DHAP
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End of stage I Converted glucose into 2 trioses Used 2[ATP] Next, “pay-off” stage
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Step 6: glyceraldehyde-3-phosphate dehydrogenase (First high-energy intermediate formation) Oxidation and phosphorylation of GAP by NAD+ and Pi
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BPG is converted to 3PG and ATP (2 ATP total)
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This document was uploaded on 03/29/2011.

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Lecture_3_-_Jan_21 - Stage I (rxns 1-5): preparatory stage...

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