spring08_homework_8

spring08_homework_8 - Biol 241 Spring 2008 Homework 8 Due...

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Biol 241, Spring 2008 Homework 8 Due 3/28/2008 Purdue ID_________________ 1 1. Question 1 (5 points, 1 point each). Many of oncogenic mutations are dominant. Which of the following general types of mutations have the potential to create dominant oncogenes? Justify each answer. a. a mutation that increases the number of copies of a transcriptional activator of cyclin A. b. a nonsense mutation located shortly after the beginning of translation in a gene that encodes a growth-factor receptor. c. a mutation in E2F that disrupts its ability to bind RB. d. a mutation that disrupts the active site of a cytoplasmic tyrosine-specific protein kinase. e. a translocation that joins a gene encoding an inhibitor of apoptosis to an enhancer element for gene expression in the liver.
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Biol 241, Spring 2008 Homework 8 Due 3/28/2008 Purdue ID_________________ 2 Question 2 (2 points, 1 point each). As we discussed in class, the oncogene erb B is a constitutively active form of a receptor tyrosine kinase that sends unregulated signals, from the plasma membrane, to stimulate cell proliferation. Suppose you have the capability to mutate all the copies of Ras genes in these erb B-expressing cells, will this enhance or suppress the ability of erb B to promote tumor progression? Please briefly explain.
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This note was uploaded on 03/30/2011 for the course BIOL 241 taught by Professor Henrychang during the Spring '10 term at Purdue.

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spring08_homework_8 - Biol 241 Spring 2008 Homework 8 Due...

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