Lecture 5 KidneyGI F09 - ANATOMY OF THE KIDNEY GLOMERULAR...

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1 ANATOMY OF THE KIDNEY GLOMERULAR FILTRATION REABSORPTION ACID-BASE CONCENTRATION/DILUTION OF URINE COUNTERCURRENT MULTIPLICATION ADH OVERVIEW of the digestive system ESOPHAGUS AND STOMACH
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2 RENAL CORTEX (blood vessel/kidney; filtration) RENAL MEDULLA (blood vessel/kidney; secretion/reabsorption) RENAL PYRAMID RENAL PELVIS URETER RENAL ARTERY RENAL VEIN
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3 CATEGORIES OF NEPHRONS CORTICAL JUXTAMEDULLARY SHORT LOOPS LONG LOOPS >>>Epithelial Cells/Na + pumps >>>interstitial osmolarity >>>Water Resorption MEDULLA CORTEX
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4 Beaver 500 Humans Australian Hopping Mouse 1200-1400 10,000 URINE CONCENTRATING ABILITY Osmolarity of the Interstitial Fluid in renal medulla mOsm/liter <<< = >>>> Juxtamedullary Nephrons
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5 COUNTERCURRENT MULTIPLICATION Antidiuretic Hormone (ADH)
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6 POSTERIOR PITUITARY growth hormone thyroid stimulating hormone adrenocorticotropic hormone follicle stimulating hormone luteinizing hormone prolactin ADH is Secreted by Axonal Nerve Endings into the Circulatory System (hyperosmotic conditions) Posterior Pituitary ADH is Produced in Neurosecretory Cells of the Hypothalmus OSMORECEPTORS (sense elevated plasma osmolarity)
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7 +H 2 O CHANNELS CONCENTRATED URINE NO H 2 O CHANNELS DILUTE URINE URINE CONCENTRATION AND DILUTION High ADH (Blood Osmolarity >300mOsmoles/L) Low ADH (Blood Osmolarity < 300mOsmoles/L)
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8 OSMOLARITY NEGATIVE FEEDBACK MECHANISM Extracellular osmolarity Osmoreceptors Neursecretory Cells Hypothalmus ADH Secretion ADH Receptors Aquaporin Secretion H 2 O reabsorption - Dehydration Deviation from Set Point Sensor Integration Center Effectors Return to Set Point
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9 ANATOMY OF THE KIDNEY GLOMERULAR FILTRATION REABOSRPTION The Kidney Regulates ACID-BASE Balance CONCENTRATION/DILUTION OF URINE COUNTERCURRENT MULTIPLICATION ADH
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10 basolateral membrane apical membrane Nephron Lumen Interstitial Space CO 2 + H 2 O H 2 CO 3 HCO
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Lecture 5 KidneyGI F09 - ANATOMY OF THE KIDNEY GLOMERULAR...

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