Problem_set_1_key

Problem_set_1_key - BIS104-002 Fall 2007 Problem Set I Due...

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BIS104-002 Fall 2007 Problem Set I “Due” Jan 13 1-3. In studying tumor cells, you isolate gene X that causes protein Q to become tyrosine phosphorylated (the addition of a phosphate group to a tyrosine). You isolate a homozygous null mutation in gene X and now find that protein Q is not tyrosine phosphorylated. Furthermore, the tumor cells are now behaving more like normal cells. 1. You conclude the following: A. Gene X is sufficient for phosphorylation of Protein Q B. Gene X is necessary for phosphorylation of Protein Q C. Gene X is necessary and sufficient for phosphorylation of Protein Q 2. If you concluded that Gene X is necessary, describe an experiment to test whether Gene X is sufficient. If you concluded that Gene X is sufficient, describe an experiment to test whether Gene X is necessary. To test if gene X is sufficient, recombinant protein encoded by gene X could be produced, mixed in a test tube with Protein Q, ATP and the transfer of phosphate to actin monitored. Since protein X, protein Q and ATP are the only things added to the reaction and then if Q becomes phosphorylated, we can conclude that protein X is sufficient. 3. In addition, you can conclude the following about gene X from the tumor cells: A. Gene X has nothing to do with cancer progression. B. Gene X is an oncogene. C. Gene X is a proto-oncogene. D. Gene X is a tumor suppressor gene E. Gene X is both proto-oncoene and a tumor suppressor gene.
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4-5. Below is a schematic diagram of a cell and with three proteins highlighted (1, 2 and
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Problem_set_1_key - BIS104-002 Fall 2007 Problem Set I Due...

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