Gen371 Sample Final Answer Key

Gen371 Sample Final Answer Key - Gen371 Sample Final Answer...

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1/26/11 4:19 PM Gen371 Sample Final Answer Key Page 1 of 8 http://courses.washington.edu/au371mkr/resources/problems/sample_final-key.html Sample Final Exam -- answers 1. The following pedigree was constructed while mapping genes for coat color in dogs. A new locus, termed Black , is thought to be responsible for black fur in these dogs. This locus is separate from previously described loci and its exact map location is unknown. Answer the following questions using B and b for dominant and recessive alleles, respectively, as appropriate. (a) I-1 was shown to be homozygous for the dominant black allele. Show the cross(es) and expected result(s) that could have led to this conclusion. You are not limited to this pedigree. Testcross I-1 (e.g., with I-2); all progeny should be black. (If I-1 were heterozygous, that cross would yield black and non-black in 1:1 ratio.) Note: You can't assume that just because some polymorphic markers are homozygous, the Black gene is homozygous also -- we don't know beforehand that the Black gene is contained within this region. (b) Each individual in this pedigree was genotyped and phase was determined at 4 markers (E-H) on the same chromosome as the Black locus. Each haplotype is shown vertically, but the origin of the haplotype (i.e., from the egg or sperm) is not shown. Both I-1 and I-3 were known to be homozygous for the dominant black allele. In the empty boxes below dog III-12, indicate which haplotype in that dog was maternally derived ( M ) and which was paternally derived ( P ). Draw a box around every haplotype or any part thereof that unambiguously was inherited from either I-1 or I-3 by any of their descendants. Based on this information, where could the Black locus be? (e.g., below Marker X, above Marker Y, between X and Y, not on this chromosome. Note that there are no Markers X and Y, those are just given as examples.) List all individuals supporting your conclusion. Location of Black locus: Below E, above F Correction: above H Individuals supporting your conclusion: III-4 and III-9 exclude E and above; III-6 excludes H and below. Notes: Home Course mechanics Help hours Calendar Syllabus Lectures, Podcasts Quiz Sections Practice problems Exams GoPost Send email to class Useful links The Gradiator
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1/26/11 4:19 PM Gen371 Sample Final Answer Key Page 2 of 8 http://courses.washington.edu/au371mkr/resources/problems/sample_final-key.html This is not an association study, it is linkage analysis based on recombination breakpoints. I-1 and I-3 are effectively unrelated individuals, so the fact that they both have the same genotype at markers F and G shouldn't be taken to mean anything. See the last question on the cystic fibrosis homework in QS8. (c)
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Gen371 Sample Final Answer Key - Gen371 Sample Final Answer...

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