Genome 371 Lecture 5

# Genome 371 Lecture 5 - Genome 371 Lecture 5 1/26/11 4:16 PM...

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1/26/11 4:16 PM Genome 371 Lecture 5 Page 1 of 20 http://courses.washington.edu/au371mkr/resources/lecture_notes/lecture_05.html Lecture 5 Mutations and Phenotypes-1 15 Oct 2010 Lecture 5 handout (pdf) Subscribe to podcast: Slide 1 Slide 2 Home Course mechanics Help hours Calendar Syllabus Lectures, Podcasts Quiz Sections Practice problems Exams GoPost Send email to class Useful links The Gradiator

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1/26/11 4:16 PM Genome 371 Lecture 5 Page 2 of 20 http://courses.washington.edu/au371mkr/resources/lecture_notes/lecture_05.html Slide 3 Slide 4 Slide 5 Slide 6
1/26/11 4:16 PM Genome 371 Lecture 5 Page 3 of 20 http://courses.washington.edu/au371mkr/resources/lecture_notes/lecture_05.html Slide 7 Slide 8 Slide 9

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1/26/11 4:16 PM Genome 371 Lecture 5 Page 4 of 20 http://courses.washington.edu/au371mkr/resources/lecture_notes/lecture_05.html Slide 10 "90% of the time expect a deviation this large". .. meaning, even if there really is an underlying 9:3:3:1 ratio, if we were to repeat Mendel's experiment a whole bunch of times, 90% of the trials would show a deviation of this magnitude from the expected values. Incidentally, when we say "this large" we aren't making a value judgement of how big the deviation is; we are saying a deviation of this magnitude (regardless of whether it's a large deviation or a small deviation). Slide 11 Slide 12 Slide 13
1/26/11 4:16 PM Genome 371 Lecture 5 Page 5 of 20 http://courses.washington.edu/au371mkr/resources/lecture_notes/lecture_05.html Slide 14 1. A and B loci should be on the same arm of the chromosome 2. Arrangement on the two homologues should be Ab/aB 3. Sister chromatids are not identical 4. No crossovers shown 5. Non-sisters showing cohesion 6. Based on the colors of the chromatids, the allele and the chromatids are mismatched at the lefthand end of the chromosomes. Slide 15 Slide 16

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1/26/11 4:16 PM Genome 371 Lecture 5 Page 6 of 20 http://courses.washington.edu/au371mkr/resources/lecture_notes/lecture_05.html Slide 17 Slide 18 Slide 19 Keeping in mind that alleles of a gene are different versions of the sequence that make up the gene. .. the "wild type" sequence (e.g., as shown on the left) is the wild type allele; every change to that sequence would give a different allele. Depending on your intent, you could represent different levels of detail about the genotype. For example, if all you want to convey is wild type vs. non-wild type, you could just say C (wild type) or c (non-wild type). But if you wanted to convey more specific information, you could use a more detailed allele designation -- e.g., c G129A to indicate that it is a non-wild type allele ( c ) in which position 129 has been changed from G to A. Likewise, c A253T could be another allele. And if you had a version that had both these mutations (i.e., both G129A and A253T ), that would be yet another allele distinct from either single mutation.
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## This note was uploaded on 03/31/2011 for the course GENOME 371 taught by Professor Unsure during the Spring '03 term at University of Washington.

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Genome 371 Lecture 5 - Genome 371 Lecture 5 1/26/11 4:16 PM...

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