ER_Protein_Import(4) - ER Protein Import Click to edit...

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Click to edit Master subtitle style ER Protein Import SRP54p
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Contains methionine-rich M domain Binds signal peptides Methionine side chains are flexible ; might enable binding to diverse sequences SRP54p GTP-binding protein Summary of SRP Interactions
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Targeting Complex: Formation and Recruitment to ER Membrane Factors: Pore opening Figure 12-40 Molecular Biology of the Cell (© Garland Science 2008) Protein Pore is closed when Targeting Complex Docks at ER
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MOVEMENT OF PROTEINS INTO ER 3 ER FACTORS: Two receptors and a translocon SRP Receptor (SRP) Ribosome receptor Translocation complex (translocon = translocator) SRP Receptor (SR) Heterodimer: contains SR α and SR β SR β is transmembrane protein SR α is a peripheral membrane protein Both SR α and SR β bind GTP Sec61p
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The Translocon Sec61 complex ( α, β , γ ) Binds ribosome ( i.e., high affinity ribosome receptor ) Associates with ribosomal RNA (large subunit (28S)) Recognizes signal peptide at ER membrane Forms the “gated” pore in lipid bilayer Ten transmembrane regions Sec61p in membrane
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This note was uploaded on 04/03/2011 for the course CBIO 3400 taught by Professor Shen,kipreos during the Spring '08 term at University of Georgia Athens.

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ER_Protein_Import(4) - ER Protein Import Click to edit...

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