MF_endocytosis

MF_endocytosis - Introduction Dr Vincent Starai Vinny Dr...

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Introduction Dr. Vincent Starai: Vinny, Dr. Vinny, Hey, you! I’m not “good” with Dr. quite yet… I’m in the Microbiology Dept., but I know a *little* about Cell Biology- lucky you! No set office hours. If you need to talk to me, email: [email protected], or call 542-5755 Lab studies pathogen interactions with eucaryotic endomembrane system, therefore on with the show!
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Eucaryotic Cell: Intracellular Organelles Our guided tour of the cell leaves the plasma membrane, and starts on a circuit of the intracellular membrane bound organelles. topology
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Topological Relations Among Compartments: Cellular space is topologically inside or outside Protein Traffic
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Road Map of Protein Traffic The organelles are distinctive in structure and function. At the same time, there is extensive movement of materials between the different organelles. This transport between intracellular compartments occurs by three different processes: gated, transmembrane, and vesicular transport. Vesicle Budding/Fusion
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Vesicular Transport: Budding and Fusion Plasma Membrane Endocytosis or Secretion Fusion or Budding of Intracellular Membranes Biosynthetic and Endocytotic Pathways
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Biosynthetic and Endocytic Pathways Must balance membrane flow in each compartment. There are multiple pathways: Green: endocytic Red: biosynthetic Blue: retrieval Types of Endocytosis
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Modes of Uptake Bulk Binding Large Clathrin Solute Surface Particle Pinocytosis yes no no no (drinking) Macropinocytosis yes no no no (gulping) Phagocytosis no yes yes no (eating) Receptor no yes no yes Mediated
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