Mitochondria_Protein_Import2011

Mitochondria_Protein_Import2011 - Protein Import into...

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Click to edit Master subtitle style Protein Import into Mitochondria Multiple pathways
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Two Membranes, Five Protein Translocases Figure 12-23 Molecular Biology of the Cell (© Garland Science 2008)
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Click to edit Master subtitle style Protein Import Pathways 4 Destinations for proteins Summary of pathways
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Proteins move across or insert into membranes of mitochondrion Outer membrane Tom Complex ( T ranslocase of O uter M embrane) SAM complex ( S orting and A ssembly M achinery) Inner membrane Tim23 complex ( T ranslocase of I nner M embrane); Presequence translocase) Tim22 complex (Carrier Translocase) Targeting into matrix OR membranes depends on different signal peptides Outline of matrix import
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Outline of Protein Entry into Matrix Receptors Figure 12-25 Molecular Biology of the Cell (© Garland Science 2008)
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Two Receptors: Tom20 and Tom70 Signal peptide(s) determine the receptor used Tom20/22 binds M atrix T argeting S ignal (MTS) Tom70 binds internal targeting domains Internal Targeting Signals Chaperones in cytoplasm: Cytosolic Hsp70 (cHsp70), Hsp40, and Hsp90 cHsp70/ Hsp40 delivers preprotein to Tom20 cHsp70/ Hsp90 target membrane proteins to Tom70
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Click to edit Master subtitle style Internal Targeting Signals Hsp70/hsp90 bind to hydrophobic precursors ü Have multiple internal targeting signals Cargo (preprotein) is delivered to Tom70 Multiple Tom70 molecules bind to single cargo Tom70 aggregates In presence of ATP , cargo is transferred to Tom40 MTS and is receptor
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