Protein Synthesis I - Protein Synthesis Initiation Click to...

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Click to edit Master subtitle style Protein Synthesis Initiation mRNA
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Features of Eukaryotic mRNAs 5’ End 1. Cap § Bound by Protein Synthesis Initiation Factors 2. Untranslated Region (5’ UTR) § Contributes to selection of selection of translation start 3’ end 1. Poly(A) “tail” § Influences initiation of translation Ribosome
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The Ribosome 4 ribosomal RNAs ( rRNAs ) 82 polypeptides Ribosome is a translation “machine”: mRNA is the Template for protein synthesis Major issues Figure 6-63 Molecular Biology of the Cell (© Garland Science 2008)
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Amino acids are attached to tRNAs ( Aminoacyl-tRNA synthetases ) Delivery of aminoacyl-tRNAs to ribosome ( Initiation factors ) Ribosome finds mRNA ( UTRs and Initiation Factors ) Selection of correct initiation codon/reading frame ( tRNA/ribosome ) Peptide bond is formed ( Ribosome ) Elongation of peptide chain ( Ribosome ) Termination of polypeptide synthesis ( Release Factors/Ribosome ) Road Map Aminoacyl-tRNA Synthetase
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1. Joins amino acid to its tRNA 2. Each amino acid has a specific aminoacyl-tRNA synthetase 3. An aminoacyl-tRNA synthetase can “charge” several tRNAs with different anticodons 1. t-RNA charging occurs at the 3’ terminus, at an
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This note was uploaded on 04/03/2011 for the course CBIO 3400 taught by Professor Shen,kipreos during the Spring '08 term at University of Georgia Athens.

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Protein Synthesis I - Protein Synthesis Initiation Click to...

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