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Updated_Golgi(6)

Updated_Golgi(6) - Golgi Structure and Functions Structure...

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Golgi: Structure and Functions Structure of Golgi
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Golgi structure and location • Vertebrate Golgi is detected as stack (EM) • Each Golgi stack has 4-6 cisternae • Cisternae : Flattened sac-like vesicles Rims are dilated • Golgi is located near the center of the cell Sub-regions of Golgi
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Golgi stacks have “sidedness” Cis face: close to nucleus Trans face: away from nucleus Medial : between cis and trans cis and trans Golgi have network of interconnected tubules and vesicles Cis-Golgi network (CGN) Trans-Golgi network (TGN) ER Vesicles enter Golgi from the cis -side Functions of Golgi
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Functions of the Golgi complex Carbohydrate 1. Processing of N-glycans on proteins 2. Lipid glycosylation (glycolipid production) Phospholipid Synthesis •. Sphingomyelin synthesis Sorting Proteins within Secretory Pathway 1. Secretory vesicles 2. Endosomes 3. Lysosomes 4. Plasma membrane 5. Endoplasmic reticulum ( retrograde transport ) Types of N- glycans
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Processing of Oligosaccharides in the Golgi 3 Classes of N-glycans: High mannose, Complex, and Hybrid Common property: Tri-mannosyl core , GlcNAc2-Man3 High mannose Core is substituted solely with Mannose Complex glycans Tri-mannosyl core Glycosidic linkages
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Complex oligosaccharide Complex and Hybrid Oligosaccharides Hybrid oligosaccharide (mannose and others terminate)
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Complex vs hybrid oligosaccharide 7 Hybrid oligosaccharide ends in mannose + others Complex oligosaccharide never ends in mannose High mannose oligosaccharide always ends in mannose Hybrid oligosaccharides are small % of total glycoproteins Processing in Stacks of Golgi
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