Vesicle Transport

Vesicle Transport - Vesicle Transport Click to edit Master...

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Click to edit Master subtitle style Vesicle Transport Major questions
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Pathways for Intracellular Vesicle Transport Vesicles bud and fuse during transport of materials Major Issues Machinery responsible for budding and fusion? How is organelle identity of maintained? Summary of Pathway
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Outline of Vesicle Formation and Fusion Coated vesicles: 2
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COATED VESICLES Are intracellular transport vesicles 1. Clathrin-coated vesicles 2. Coatomer-coated vesicles: COPI and COPII Involved in “ un-selected cargo” vesicle transport Location of coat proteins Figure 13-4 Molecular Biology of the Cell (© Garland Science 2008)
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COPs form Vesicles in Different Cellular Locations COPII : ER-to-Golgi transport (anterograde) COPI : Intra-Golgi; (ii) Endosomes; (iii) Golgi-to-ER COP composition Figure 13-5 Molecular Biology of the Cell (© Garland Science 2008)
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COAT PROTEINS (COPS) COPI complex 1. Seven subunits ( α, β, β , γ , δ, ε, ζ ) (700 kDa) 2. A DP R ibosylation F actor ( Arf ) COPII complex 1. Subunits: Sec23p , Sec24p , Sec13p and Sec31p 2. Sar1p (related to ARF) Sec12p is GNEF for Sar1p ARF
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ADP Ribosylation Factor (ARF1) 1.
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