Chapter 16 Gluconeogenesis 5) G6Pase is particularly dangerous because it is not converted into free glucose immediately, rather into glycogen. This is the case because the enzyme responsible for converting G6Pase into free glucose, glucose 6-phosphatase, is regulated. Secondly, the enzyme is present only in metabolic tissues in which the metabolic duty is to maintain blood-glucose homeostasis. Fructose1,6-biphosphatase is an enzyme that participates in the regulation of gluconeogenesis. Depending on the next reversible step in the sequence steps, gluconeogensis predominated until the next irreversible step is reached. G6Pase is hydrolyzed into Glucose by G6Phospatase and a Ca2+ special protein(this protein stabilizes G6Phospatase). After, the glucose and the free phosphate group are transported out of the endoplasmic reticulum into the cytoplasm (T2 and T3 protein transport out and T1 protein brings in the G6Pase). 6) The lower part of the pathway is common to glycolysis and gluconeogenesis. The four
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