Class01-ClassSlides-Spring 2011-03082011

Class01-ClassSlides-Spring 2011-03082011 - Genetic Analysis...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Genetic Analysis II (385) – Population Genetics Lecture 01 Date: 03/08/11 Instructor: Professor Derek Gordon Office: Life Sciences Building, Room 128 Phone: 445-3386 Phone: 445 3386 Office Hours: Tues, Thurs: 12:00pm – 1:15pm, and by appt. Transmission Genetics: functions at organism level concerns flow of genes in families. concerned with Mendelian ratios concerned with Mendelian ratios, gene expression, etc. 3/8/2011 Class01-Spring2011 2
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Transmission Genetics: functions at organism level concerns flow of genes in families. concerned with Mendelian ratios concerned with Mendelian ratios, gene expression, etc. Molecular Genetics Study of structure, function of macromolecules. Replication, transcription, translation. 3/8/2011 Class01-Spring2011 3 Transmission Genetics: functions at organism level concerns flow of genes in families. concerned with Mendelian ratios concerned with Mendelian ratios, gene expression, etc. Molecular Genetics Study of structure, function of macromolecules. Replication, transcription, translation. 3/8/2011 Class01-Spring2011 4 Population Genetics: Study the frequencies of alleles (genes) and the changes in gene and genotype freq. over time (generations).
Background image of page 2
3 Essential Definitions Allele Frequency *Essential Definition The proportion or frequency of a particular allele of all the possible alleles for that gene (or locus). The sum of all allele frequencies at a locus must sum to 1 . Example: A 1 = .4 and A 2 = .6 3/8/2011 Class01-Spring2011 5 Essential Definitions Genotype frequency *Essential Definition The proportion of the population possessing a particular genotype. The proportion is usually given in terms of a specified number of loci (e.g., 1, 2, 3, ...). 3/8/2011 Class01-Spring2011 6 For example – one locus with two alleles A 1 and A 2 would have three genotypes A 1 A 1 , A 1 A 2 , and A 2 A 2.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Essential Definitions allele array *Essential Definition The array of all allele frequencies at a locus. They must, by definition sum to one (1 ). For example, if the frequency of A 1 = p and the freq. of A 2 = q then the allele array would be p + q = 1. 3/8/2011 Class01-Spring2011 7 If the locus had a third allele in the gene pool A 3 with freq. of r , then the allele array would be p + q + r = 1. Essential Definitions Genotype Array : *Essential Definition The array of all possible genotypes at one or more loci. For one locus with two alleles, A 1 and A 2 , there are three genotypes: A 1 A 1 , A 1 A 2 , & A 2 A 2 with respective frequencies of X, Y, Z. 3/8/2011 Class01-Spring2011 8 The genotype array would be X + Y + Z = 1 .
Background image of page 4
5 Essential Definitions Gene pool *Essential Definition The sum total of all alleles of all genes (or of all gametes) in the population (i.e, the “genetic universe”). Conceptually one draws two gametes from the gene pool in order to make up individuals for the next generation. 3/8/2011 Class01-Spring2011 9 Essential Definitions Population : *Essential Definition A group of potentially sexually interbreeding organisms that share a common gene pool. The term implies a geographical continuity.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/04/2011 for the course GENETICS 385 taught by Professor Brennemanandgordon during the Spring '11 term at Rutgers.

Page1 / 29

Class01-ClassSlides-Spring 2011-03082011 - Genetic Analysis...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online