GeneticHomologyExample

GeneticHomologyExample - Gene Similarity: Some Definitions...

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Department of Microbiology The JHJ-Lab TECHNICAL REPORTS REVIEWS Report Number Topic Author(s) Introduction This explanation of current and popular genomic jargon is prepared primarily as an aid to undergraduates at Michigan State University who are new to this area of research, and especially those beginning work in the JHJackson lab. As such, this treatment is informal by design in effort to make the information maximally accessible. The intent of scientific vocabulary or terminology is to create a precision of definition such that any topic may be discussed with unambiguous meaning. In the midst of the current information explosion resulting from new sequence acquisitions, terminologies are continuously being constructed to characterize genes and proteins according to knowledge or inferences about their origins and activities. Here is a partial listing of some terms to define or describe gene and protein similarity that have come into common use. A brief definition or description accompanies each term. These few examples should illustrate that terms used can easily become terms confused , and that expansion of terms frequently may not expand precision of understanding. A key point of confusion results from a much more rapid expansion of information than knowledge from the information. The continued addition of new terms truly expands information, . .. and sometimes knowledge. Definitions Heterologs. { Heterologs differ in both origin and activity. } Genes that are "unique" in activity and sequence are said to be heterologous. Note that genes initially defined as heterologous by syntax (letter matching) may actually be homologous by activity. Homologs. { Homologs have common origins but may or may not have common activity. } Genes that share an arbitrary threshold level of similarity determined by alignment of matching bases are termed homologous . Homology is a qualitative term that describes a relationship between genes and is based upon the quantitative similarity. Similarity is a quantitative term that defines the degree of sequence match between two compared sequences. Homology implies that the compared sequences diverged in evolution
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This note was uploaded on 04/04/2011 for the course GENETICS 385 taught by Professor Brennemanandgordon during the Spring '11 term at Rutgers.

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GeneticHomologyExample - Gene Similarity: Some Definitions...

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