181lec4.key - Psych 181: Dr. Anagnostaras Lecture 4:...

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Psych 181: Dr. Anagnostaras Lecture 4: Behavioral Pharmacology Behavioral Pharmacology Behavioral Pharmacology The study of the relationship between the physiological actions of drugs and their effects on behavior and psychological function Drugs do not create behaviors outside the normal species-typical repertoire They alter the probability of occurrence of behaviors 1 2 3 Sunday, January 9, 2011
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Set and setting The behavioral effects of drugs are due to complex interactions amongst the pharmacological actions of drugs, the state of the organism (“set”), and the environmental circumstances surrounding drug administration (“setting”) Evaluating the behavioral effects of drugs Primary Evaluation Unconditioned effects on behavior Motor activity locomotion, catalepsy, balance, strength Seizures Eating and drinking Secondary evaluation Tests of more speciFc functions (either unconditioned or conditioned (learned) Analgesia Hot plate test Tail-flick test Light source 4 5 6 Sunday, January 9, 2011
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Secondary evaluation Learning and memory -several different forms Spatial Radial Maze Task Lots of spatial (room) cues All arms baited, must not revisit arms Rats/mice use these cues to avoid revisiting arms (ecologically valid) •Different brain systems than non-spatial “Win-Shift” •Different brain systems than visible platform •Measure latency to mount plaform & swim path (distance traveled to platform) •Use spatial cues in room (posters, etc) to locate submerged platform (same place ea. time) 7 8 9 Sunday, January 9, 2011
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Fear and Anxiety 10 11 12 Sunday, January 9, 2011
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Secondary Eval • Anxiety • Elevated Plus Maze end for Self-administration (Lecture 4 continued) Schedules of reinforcement Positive reinforcement Presentation increases the probability of the preceding behavior Negative reinforcement Removal increases the probability of the preceding behavior Punishment Decreases the probability of a behavior 13 14 15 Sunday, January 9, 2011
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181lec4.key - Psych 181: Dr. Anagnostaras Lecture 4:...

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