181lec5.key - Psych 181: Dr. Anagnostaras Lecture 5...

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Psych 181: Dr. Anagnostaras Lecture 5 Synaptic Transmission Introduction to synaptic transmission Synapses (Gk., to clasp or join) Site of action of most psychoactive drugs 6.5 1 2 3 Sunday, January 9, 2011
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Synapses Know basic terminology: Soma Axon Dendrite Synaptic vesicles Synaptic cleft Postsynaptic Presynaptic Glia 6.2 1 2 4 5 6 8 7 3 Synapses Dendrites & spines 3.10 Synapses Types of cell-cell junctions Tight junctions membranes fused Gap junctions close juxtaposition (2-4 nm) electrical synapse Chemical synapses synaptic cleft (20-30 nm) polarized 4 5 6 Sunday, January 9, 2011
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Multiple types of synapses Vesicle varieties 6.4 Spherical agranular vesicles Reciprocal junction Spherical granular Flattened vesicles 6.3 + - Multiple types of synapses Multiple patterns of connectivity Axodendritic Dendrodendritic Axoaxonic Axosomatic etc. 6.1 Steps in synaptic transmission Synthesis Transport Storage Release Inactivation 7 8 9 Sunday, January 9, 2011
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Release Excitation-secretion coupling Depolarization Open voltage-gated Ca ++ channels Ca ++ infux Bind to Ca ++ -calmodulin protein kinase Phosphorylation oF synapsin I Movement oF vesicles to release site Exocytosis DiFFusion Exocytosis 6.17 Inactivation Reuptake transporters Enzymatic degradation metabolism excretion cycling DOPAC DOPA Tyrosine Extracellular DOPAC Extracellular DA Monoamine oxidase HVA Dopamine transporter Cytoplasmic DA Releasable DA COMT 3-MT 8.13 10 11 12 Sunday, January 9, 2011
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Sample question In which of the following are the events listed in the correct temporal order (i.e., the temporal order associated with excitation-secretion coupling)? (a)
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This note was uploaded on 04/01/2011 for the course PSYCH 181 taught by Professor Fick during the Spring '11 term at University of Tennessee.

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181lec5.key - Psych 181: Dr. Anagnostaras Lecture 5...

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