181lec11.key - Psych 181: Dr. Anagnostaras Lec 11: PCP and...

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Psych 181: Dr. Anagnostaras Lec 11: PCP and Hallucinogens Phencyclidine Dissociative anaesthetic Parke Davis in 1950 (Serylan® Serynl®) withdrawn from human use in 1965 related to ketamine (“K” Ketalar, Ketaset®) Illicit use 1967 in San Francisco (PeaCe Pill) Widespread in late 1970, ʼ s, early 1980 ʼ s (1980 - 22% of kids in grades 11-12 in N.Y.) Cheap, mostly distributed by the Crips nowadays N Phencyclidine (PCP) Street names PCP, angel dust, crystal, horse tranquilizer “sherm” “embalming fuid” on cigarettes or marijuana sold under many names and preparations very oFten sold as 9-THC take orally, intranasal or i.v.; or smoke NH O Ketamine CH3 Cl 1 2 3 Sunday, January 9, 2011
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Effects Low dose (1-5 mg) alcohol-like effect (giddy drunken-like state, disinhibition) Moderate dose (5-10 mg) distortion of space & time, psychotic reactions (panic, agitation, depression, catatonia, paranoia) “anaesthetic” and analgesic effects blank stare, amnesia, mutism Toxic psychosis High dose (> 10 mg) model of acute schizophrenia, including true hallucinations (can last up to 1-7 days with high doses) sometimes violent, abusive behavior Overdose Respiratory depression/seizures Self-administration Reinforcing effects Readily self-administered in animals to point of intoxication modest tolerance addiction and withdrawal 4 5 6 Sunday, January 9, 2011
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Mechanisms of action Two distinct binding sites Sigma site - generalizes with benzomorphans PCP site (“PCP receptor”) PCP site part of the NMDA glutamate receptor Glutamate (glutamic acid) Ubiqutious excitatory transmitter Depolarizes virtually all cells Primary transmitter for fast excitatory signalling
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181lec11.key - Psych 181: Dr. Anagnostaras Lec 11: PCP and...

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