nuerology. 2005 apr 12;hw2

nuerology. 2005 apr 12;hw2 - Cellular telephones and risk...

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Cellular telephones and risk for brain tumors A population-based, incident case-control study H. Collatz Christensen, MD; J. Schüz, PhD; M. Kosteljanetz, DMSc, MD; H. Skovgaard Poulsen, DMSc, MD; J.D. Boice, Jr., ScD; J.K. McLaughlin, PhD; and C. Johansen, PhD, DMSc, MD Abstract— Objective: To evaluate a possible association of glioma or meningioma with use of cellular telephones, using a nationwide population-based case–control study of incident cases of meningioma and glioma. Methods: The authors ascertained all incident cases of glioma and meningioma diagnosed in Denmark between September 1, 2000, and August 31, 2002. They enrolled 252 persons with glioma and 175 persons with meningioma aged 20 to 69. The authors also enrolled 822 randomly sampled, population-based controls matched for age and sex. Information was obtained from personal interviews, medical records containing diagnoses, and the results of radiologic examinations. For a small number of cases and controls, the authors obtained the numbers of incoming and outgoing calls. They evaluated the memory of the respondents with the Mini-Mental State Examination and obtained data on socioeconomic factors from Statistics Den- mark. Results: There were no material socioeconomic differences between cases and controls or participants and non- participants. Use of cellular telephone was associated with a low risk for high-grade glioma (OR, 0.58; 95% CI, 0.37 to 0.90). The risk estimates were closer to unity for low-grade glioma (1.08; 0.58 to 2.00) and meningioma (1.00; 0.54 to 1.28). Conclusion: The results do not support an association between use of cellular telephones and risk for glioma or meningioma. NEUROLOGY 2005;64:1189–1195 Little is known about the risk factors for tumors of the brain. 1 Although some attention has been given to the radiofrequency fields emitted from cellular telephones, the fact that they do not have enough energy to break chemical bonds or damage DNA 2 raises doubt that they could cause cancer. 3,4 As radio- frequency fields are unlikely to cause gene muta- tions, the proposed biologic process underlying a possible association between use of cellular tele- phones and the risk for cancer is a thermal or a non-thermal mechanism that promotes tumor growth. 5-7 Of the epidemiologic studies of tumors of the brain and radiofrequency fields from cellular telephones, 4,8-11 only one showed a significantly in- creased risk for tumors after long-term use of cellu- lar telephones or cordless telephones. 12-15 The latter studies have, however, been criticized on a number of methodologic bases. 16-18 We report here the results of the Danish compo- nent of the Interphone project, which was initiated as an international incident case-control study of glioma, meningioma, parotid gland tumors, and acoustic neuroma with a common protocol in 13 countries.
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nuerology. 2005 apr 12;hw2 - Cellular telephones and risk...

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