HC70A_W09_1-13-09-Lecture2

HC70A_W09-Le - HC70A SAS70A Winter 2009 Genetic Engineering in Medicine Agriculture and Law Professors Bob Goldberg John Harada Lecture 2 What Are

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HC70A & SAS70A Winter 2009 Genetic Engineering in Medicine, Agriculture, and Law Professors Bob Goldberg & John Harada Lecture 2 What Are Genes & How Do They Work: Part One Course Administratorp
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THEMES 1. What is the Function of a Gene? 2. What are the Properties of Genes? 3. What is the Evidence That DNA is the Genetic Material (Griffith and Avery Experiments)? 4. Is Transformation Universal? 5. What is the Structure of DNA? 6. What is the Structure of a Chromosome? 7. What is the Anatomy of a Gene? 8. What is the Colinearity Between Genes & Proteins (how does DNA protein)? 9. How Do Switches Work to Control Gene Activity? 10.What Are the Possibilities For Manipulating Genes in the Future?
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If You Were on the Nobel Prize Committee, Who Would Be Your Choice(s) For Being Awarded the Nobel Prize For Discovering the Structure of DNA? a. Watson b. Crick c. Wilkins d. Franklin e. Gosling f. Chargaff Note : Nobel Prize Rules Allow Only Three People To Share a Prize
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Last Lecture -- Age of DNA & Genetic Engineering Today ` s Class -- What ARE Genes & How Do They Work? PART ONE Demonstration Bacterial l Cloning z & Gel Electrophoresis
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Recall: We Live in the The Age of DNA! Genetic Engineering Is Manipulating DNA! Understanding Genetic Engineering Requires a Basic Understanding of Genes And How They Work
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What Are the Functions of a Gene? 1. Replication 2. Gene Action 3. Cell Function (Trait) Genetic Engineering Alters Cell Function By Changing the Genotype How is this Demonstrated Experimentally? Design an Experiment! Genotype Phenotype Collection of Genes Collection of Traits 5 ` 3 ` 5 ` 3 ` 3 ` 5 `
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Gene Action Leads to Specific Traits Trait (e.g., Green Seeds) Alleles Mutations Lead to Different Forms of the SAME Gene (Alleles) and Generate Genetic Variability in a Population of Organisms (e.g., round and wrinkled peas) Genetic Engineering Can Create Infinite Amounts of Genetic Variability NOT Found in Nature (+ Rare Mutations) Mendel ` s Traits
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Breeding Uses Natural Genetic Variability of Genes As Raw Material - Variability Generated by Mutations This Genetic Variability Arose Spontaneously By RARE Mutations Gene Mutations Alter DNA Sequences, Slightly Change Gene Functions (e.g., fruit size, color), & Create Alleles -- Different Forms of the Same Gene
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Alleles Are Different Forms of the Same Gene That Arise By Mutation & Can be Made in a Laboratory By Modern Genetic Engineering! Alleles Alleles Reside at the Same Position on a Chromosome
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How Does the GloFish Experiment Show That Genes Direct the Production of Traits? Traits Phenotypes D i f f e r e n t Colors!! What ` s Your Hypothesis ?
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1. Replication 2. Stability (Mutations) 3. Universality a) All Cells b) All Organisms 4. Direct Cell Function/Phenotype WHAT ARE THE PROPERTIES OF A GENE? How Can These Properties Be Tested Experimentally?
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This note was uploaded on 04/05/2011 for the course ENG 262 taught by Professor Tolda during the Fall '09 term at Grand Valley State University.

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HC70A_W09-Le - HC70A SAS70A Winter 2009 Genetic Engineering in Medicine Agriculture and Law Professors Bob Goldberg John Harada Lecture 2 What Are

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