ch369_3-2_metab1_notes

ch369_3-2_metab1_notes - The next few weeks will be about...

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The next few weeks will be about metabolism.
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Metabolism • Metabolism is the chemical reactions taking place in an organism • Heterotrophs – use organic carbon as food • Autotrophs – use inorganic carbon as food • Subtypes of metabolism within cells - Catabolism (complex ==> simple molecules) Anabolism (simple ==> complex molecules)
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Clicker question. Which is an example of an autotroph? A) human B) yeast C) plant D) E. coli bacteria
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Why would we want to make ATP? What’s it good for? One goal of metabolism is to make ATP. Useful energy is released when the phosphoanhydride bonds are cleaved.
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Hydrolysis of ATP releases energy. energy + +
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Some common electrophiles A common nucleophile Hydrolysis of ATP reaction mechanism.
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Hydrolysis of ATP, reaction mechanism.
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One thing that ATP is useful for is providing energy to drive the conformational change in the “motor protein” myosin .
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(Na + /K + transporter uses the energy of ATP hydrolysis to move ions against a concentration gradient) Also, active transport requires energy, which can be provided by ATP hydrolysis. Active transport can work against a concentration gradient.
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Something else that ATP can be used for: Energy released in ATP hydrolysis can drive chemical reactions that would otherwise be thermodynamically unfavorable. Illustrate this important point with an example.
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Consider a reaction: (not spontaneous) The “coupled reaction” is spontaneous !
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Example:
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This note was uploaded on 04/02/2011 for the course CH 369 taught by Professor Kbrowning during the Spring '07 term at University of Texas at Austin.

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ch369_3-2_metab1_notes - The next few weeks will be about...

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