ch369_3-3_glycol_notes

ch369_3-3_glycol_notes - Can you identify these molecules...

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Unformatted text preview: Can you identify these molecules ? Glycolysis What is glycolysis? A metabolic pathway that converts glucose to pyruvate. Overall reaction of glycolysis: Glycolysis is an oxidation-reduction reaction: Glucose gets oxidized to pyruvate. NAD + gets reduced to NADH. A cofactor to remember. NADH NAD + 10 steps in glycolysis. Each step is catalyzed by its own enzyme. Its time to make a few comments about each step. glucose 2 pyruvate Step 1: glucose converted to glucose-6-phosphate by hexokinase . This step uses ATP. What ??? I thought we were supposed to make ATP !!! The frst 5 steps in glycolysis are sometimes called “preparatory phase” or “energy investment phase”. Our text uses “ energy investment phase ”. Last 5 steps in glycolysis are called “generation phase” or “energy payoFF phase”. Our text uses “ energy payoFF phase ”. The last 5 steps are where the ATP is made. Hexokinase catalyzes step 1. Step 1 releases a lot of energy (therefore is essentially irreversible). ( Δ G = -16.7 kJ/mole) Δ G for this step is very small. This means the reactant and product are present in almost equal amounts at equilibrium. Step 2. Catalyzed by phosphoglucose isomerase. Oh no, we just used another ATP! Aren’t we supposed to be making ATP? We are still on the “preparatory phase”. Notes on step 3: Δ G = -14 kJ/mol, so energetically very favorable, therefore not reversible....
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ch369_3-3_glycol_notes - Can you identify these molecules...

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