Lecture 8 9-27-10

Lecture 8 9-27-10 - Lecture 8 Lecture 8 27 27 September...

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Unformatted text preview: Lecture 8 Lecture 8 27 27 September September 2010 2010 Aerobic catabolism consists of Aerobic catabolism consists of four major sets of reactions: four major sets of reactions: 1. 1. Glycolysis Glycolysis 2. Krebs cycle 2. Krebs cycle 3. Electron transport chain 3. Electron transport chain 4. Oxidative 4. Oxidative phosphorlyation phosphorlyation Glycolysis In the absence of oxygen, pyruvate is oxidized to yield lactate, with the concomittant production of 2 NAD per glucose. Yield: 2 ATP / glucose; 2 NADH 2 NAD must be re-supplied Pyruvate must be removed Anaerobic Glycolysis Substrate Endpoint mol ATP / mol substrate Glucose Lactate 2 Glucose Succinate 4 Glucose Propionate 6 Krebs Cycle roduction of 6 O 2 per glucose NADH 2 & 2 ADH 2 per glucose high-energy hosphate bonds er glucose Amino Acids feed into the Krebs Cycle as alternative fuels . Beta-oxidation of fatty acids produces acetyl-CoA for entry into the Krebs cycle . Electron Transport Complexes I, III, and IV are proton pumps. They pump H + into the intermembrance space olecular O 2 is the ultimate electron acceptor Availability of O 2 permits high yield of ATP per glucose and maintenance of redox balance. Coupling (and Uncoupling) of Electron Transport to ATP Synthesis Uncoupling of proton diffusion from ATP ynthesis occurs in tissues specialized for heat production. High-Energy Phosphagens...
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Lecture 8 9-27-10 - Lecture 8 Lecture 8 27 27 September...

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